Pyridine → n-(1h-Indol-7-yl)methanesulfonamide

HRID 13693

反応式

HRID 13693 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH2:10])[CH:3]=[CH:2]1.N1C=CC=CC=1.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>ClCCl>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH:10][S:18]([CH3:17])(=[O:20])=[O:19])[CH:3]=[CH:2]1

参加物

5

反応物 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 1116347-Aminoindole

生成物 1

HCID 20231824n-(1h-Indol-7-yl)methanesulfonamide収率 94%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Stir 1H-indol-7-ylamine with pyridine (1 equivalent) and methanesulfonyl chloride (1 equivalent) in dichloromethane for 12 hrs. Wash the reaction with 1N hydrochloric acid and water, dry over magnesium sulfate, and evaporate. Recrystallize the residue from isopropanol to obtain the title product as a purple solid (94%). MS (ES+), 210 (M), MS (ES−), 209 (M−1). LC/MS shows 95% purity.

後処理

  1. washWash
  2. customthe reaction with 1N hydrochloric acid and water
  3. dry with materialdry over magnesium sulfate
  4. customevaporate
  5. customRecrystallize the residue from isopropanol

出典と根拠

ORDレコード
ord-54e3deaf4b5a4dd0936ca7f5174fa939
出典データセット
uspto-grants-2010_06
特許番号
US07728150B2

関連ノート

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