Hydrochloric Acid → HCID 178505547、化合物
反応式
[Br:1][C:2]1[N:3]=[C:4]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[N:5](COCC[Si](C)(C)C)[CH:6]=1.Cl.O>CCO>[Br:1][C:2]1[N:3]=[C:4]([C:15]2[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=2)[NH:5][CH:6]=1参加物
5
実験手順
4-Bromo-2-(4-fluorophenyl)-1-(2-trimethylsilanyl-ethoxymethyl)imidazole (3.4 g; 9 mmol) is dissolved in EtOH (34 ml) and HCl conc. (37%; 34 ml) and heated to 55 C for 1 h. Water is added to the reaction mixture and the aqueous phase extracted three times with ethyl acetate. The combined organic phases are washed with 2N Na2CO3 and saturated NaCl-solution, dried over Na2SO4, filtered and evaporated to dryness to yiled the title compound as colorless crystals (2.1 g, 92%).
後処理
- extractionthe aqueous phase extracted three times with ethyl acetate
- washThe combined organic phases are washed with 2N Na2CO3 and saturated NaCl-solution
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated to dryness to yiled the title compound as colorless crystals (2.1 g, 92%)
出典と根拠
- ORDレコード
- ord-a664c80e776449bea362bb902320893f
- 出典データセット
- uspto-grants-2003_06
- 特許番号
- US06579874B2
反応ノート
読み込み中…