Hydrochloric Acid → 6-(1H-indole-2-sulfonyl)-2,3-dihydropyridazin-3-one

HRID 1369461ノート

反応式

HRID 1369461 の反応式
C[O:2][C:3]1[N:4]=[N:5][C:6]([S:9]([C:12]2[NH:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][CH:15]=3)(=[O:11])=[O:10])=[CH:7][CH:8]=1.Cl>O1CCOCC1>[NH:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:20]=[C:12]1[S:9]([C:6]1[CH:7]=[CH:8][C:3](=[O:2])[NH:4][N:5]=1)(=[O:11])=[O:10]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 110770903-Methoxy-6-(indole-2-sulfonyl)-pyridazine

生成物 1

HCID 98568096-(1H-indole-2-sulfonyl)-2,3-dihydropyridazin-3-one

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
100 °C

実験手順

A mixture of 3-methoxy-6-(indole-2-sulfonyl)-pyridazine (0.58 mmol, 290 mg), conc. HCl (0.5 mL), and dioxane (3 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (10 mL) was added to the residue, and the resulting solid, 6-(indole-2-sulfonyl)-2H-pyridazin-3-one was collected and dried (83%, 133 mg); mp 248° C.-249° C.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customevaporated to dryness
  3. additionWater (10 mL) was added to the residue
  4. customthe resulting solid, 6-(indole-2-sulfonyl)-2H-pyridazin-3-one was collected
  5. customdried (83%, 133 mg)

出典と根拠

ORDレコード
ord-44ac44fb91c64f5c8c7d7fc310323e74
出典データセット
uspto-grants-2003_06
特許番号
US06579879B2

反応ノート

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