Water → HCID 22672646、化合物

HRID 1369569ノート

反応式

HRID 1369569 の反応式
C[O:2][C:3]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:4]=1[CH2:5][NH:6][C:7]1[C:8]2[N:9]([C:13]([CH3:17])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1.B(Br)(Br)Br.O>C(Cl)Cl>[OH:2][C:3]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:4]=1[CH2:5][NH:6][C:7]1[C:8]2[N:9]([C:13]([CH3:17])=[C:14]([CH3:16])[N:15]=2)[CH:10]=[CH:11][CH:12]=1

参加物

5

反応物 3

HCID 962WaterHCID 25134Boron tribromideHCID 22672579HCID 22672579、化合物

生成物 1

HCID 22672646HCID 22672646、化合物収率 57%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒3 回

反応条件

温度
-73 °C

実験手順

8-(2-methoxy-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine (0.14 g, 0.48 mmol) was solved in methylene chloride (9 ml) and the mixture was cooled to −73° C. Boron tribromide in methylene chloride (1M) (2.37 ml, 2.37 mmol) was added dropwise and the mixture was stirred for 20 h. in a nitrogen atmosphere and the temperature was allowed to raise to room temperature. The reaction mixture was cooled on ice and ice, water and methylene chloride were added. The organic layer was separated, washed with saturated sodium bicarbonate, dried and evaporated under reduced pressure to give 0.077 g (57%) of the title compound.

後処理

  1. temperatureto raise to room temperature
  2. additionwere added
  3. customThe organic layer was separated
  4. washwashed with saturated sodium bicarbonate
  5. customdried
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-55ba9934d687466e8329360817cadf7b
出典データセット
uspto-grants-2003_06
特許番号
US06579884B1

反応ノート

読み込み中…