Acetic Acid → 2-Bromo-1-methoxymethyl-3-methylbenzene

HRID 1369592

反応式

HRID 1369592 の反応式
[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]Br.[C:11](=O)(O)[O-:12].[Na+].C(O)(=O)C>CO>[Br:1][C:2]1[C:9]([CH3:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][O:12][CH3:11]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 516892Sodium BicarbonateHCID 109343202-Bromo-1-(bromomethyl)-3-methylbenzene

生成物 1

HCID 138434542-Bromo-1-methoxymethyl-3-methylbenzene収率 99%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a stirred solution of 2-bromo-3-methylbenzylbromide (5.2 g, 0.0197 mol) in methanol (30 ml) was added saturated sodiumbicarbonate (5 ml) and the mixture was refluxed overnight. The mixture was neutralised with acetic acid and the solvent was evaporated under reduced pressure. Chromatography of the residue on silica gel using hexane:methylene chloride (7/3) as eluent gave 4.2 g (99%) of the title compound.

後処理

  1. temperaturethe mixture was refluxed overnight
  2. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-71cb6ed385944d218490145813e7eb64
出典データセット
uspto-grants-2003_06
特許番号
US06579884B1

関連ノート

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