Water → 2-(2-Bromo-3-methylphenyl)acetic acid
反応式
[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][C:5]#N.S(=O)(=O)(O)[OH:13].[OH2:17]>C(OCC)C>[Br:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][C:5]([OH:13])=[O:17]参加物
5
実験手順
2-bromo-3-methylbenzylcyanid (8.8 g, 42 mmol) was added to a mixture of conc sulfuric acid (50 ml) and water (60 ml) and was refluxed overnight. Water (150 ml) and diethyl ether were added and the organic layer was separated. To the organic layer was added a saturated sodium bicarbonate solution and the aqueous layer was separated. The aqueous layer was made acidic by addition of conc sulfuric acid. The acidic water solution was extracted with diethyl ether and the organic layer was washed with water, dried (Na2SO4) and evaporated under reduced pressure to give 6.5 g of the title compound.
後処理
- temperaturewas refluxed overnight
- customthe organic layer was separated
- additionTo the organic layer was added a saturated sodium bicarbonate solution
- customthe aqueous layer was separated
- additionThe aqueous layer was made acidic by addition of conc sulfuric acid
- extractionThe acidic water solution was extracted with diethyl ether
- washthe organic layer was washed with water
- dry with materialdried (Na2SO4)
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-412d421ae5e04513b37b3166611d2af2
- 出典データセット
- uspto-grants-2003_06
- 特許番号
- US06579884B1
反応ノート
読み込み中…