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1-Methoxy-4-methyl-2-nitrobenzene → 4-(Bromomethyl)-1-methoxy-2-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methoxy-4-methyl-2-nitrobenzene | HCID 67058 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 触媒 | 2,2'-Azobis(2,4-dimethyl-4-methoxyvaleronitrile) | HCID 85867 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(Bromomethyl)-1-methoxy-2-nitrobenzene | HCID 11579648 | 78.2% |
反応手順
To a solution of 4-methoxy-3-nitrotoluene (5.02 g) and N-bromosuccinimide (5.51 g) in dichloromethane (50 mL) was added 2,2′-azobis(4-methoxy-2,4-dimethylvaleronitrile) (463 mg). The mixture was heated under reflux for 8 hours. The solution was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was triturated with n-hexane-ethyl acetate (20:1) to give 4-methoxy-3-nitrobenzyl bromide as a pale yellow powder (5.78 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06582351B1 |
| 出典データセット | uspto-grants-2003_06 |
| ORD ID | ord-9b00f5281c724f9a8e1e3bef3a83a71c |
| 出典メモ | uspto-grants-2003_06 |