4-Amino-2-chlorophenol → 2-Chloro-N-(3-chloro-4-hydroxy-phenyl)-4-trifluoromethylbenzenesulfonamide

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([Cl:9])[CH:3]=1.[Cl:10][C:11]1[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[CH:13][C:12]=1[S:21](Cl)(=[O:23])=[O:22]>>[Cl:10][C:11]1[CH:16]=[C:15]([C:17]([F:19])([F:18])[F:20])[CH:14]=[CH:13][C:12]=1[S:21]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([Cl:9])[CH:3]=1)(=[O:23])=[O:22]

参加物

反応物 2

HCID 775784-Amino-2-chlorophenol

HCID 27366752-Chloro-4-(trifluoromethyl)benzenesulfonyl chloride

生成物 1

HCID 185115302-Chloro-N-(3-chloro-4-hydroxy-phenyl)-4-trifluoromethylbenzenesulfonamide

実験手順

2-Chloro-N-(3-chloro-4-hydroxy-phenyl)-4-trifluoromethyl-benzenesulfonamide was synthesized (92%) from 4-amino-2-chlorophenol (Aldrich) and 2-chloro-4-trifluoromethylbenzenesulfonyl chloride in a similar manner as described in Example 421.

出典と根拠

ORDレコード: ord-2fcf1561437e48a78e5b0b974bece6fa
出典データセット: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06583157B2

反応ノート

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