7-chloro-1H-indole → 7-Chloro-3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indole

HRID 13707

反応式

HRID 13707 の反応式
[CH2:1]([C:3]1(O)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[Cl:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:23]=1[NH:22][CH:21]=[CH:20]2>>[Cl:14][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:23]=1[NH:22][CH:21]=[C:20]2[C:3]1([CH2:1][CH3:2])[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1

参加物

3

反応物 2

HCID 1046447-chloro-1H-indoleHCID 593404281-Ethyl-5-fluoroindan-1-ol

生成物 1

HCID 115658817-Chloro-3-(1-ethyl-5-fluoro-indan-1-yl)-1H-indole

実験手順

Utilizing 1-ethyl-5-fluoro-indan-1-ol and 7-chloroindole, the title compound is prepared as in example 1. 90 mg (60%). NMR (400 MHz, CDCl3): δ 0.85 (t, 3H), 2.15 (m, 1H), 2.22 (m, 1H), 2.34 (m, 1H), 2.59 (m, 1H), 2.98 (m, 2H), 6.82 (t, 1H), 6.87 (m, 2H), 7.00 (m, 2H), 7.11 (d, 1H), 7.16 (d, 1H), 8.12 (s, 1H, NH).

出典と根拠

ORDレコード
ord-7a04d25028314e6e9dd1befb42518329
出典データセット
uspto-grants-2010_06
特許番号
US07728150B2

関連ノート

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