Potassium Hydroxide → 1-Hydroxymethyl-7-Methoxynaphthalene
反応式
C([O:4][CH2:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[CH:9]=[CH:8][CH:7]=1)(=O)C.[OH-].[K+]>CO.O>[CH3:17][O:16][C:13]1[CH:14]=[C:15]2[C:10]([CH:9]=[CH:8][CH:7]=[C:6]2[CH2:5][OH:4])=[CH:11][CH:12]=1参加物
5
実験手順
34.5 g (0.15 mol) of the compound obtained in Step A are dissolved in 300 ml of methanol. 35 g (4 eq) of potassium hydroxide dissolved in 35 ml of water are added with vigorous stirring. After 3 hours at room temperature, the reaction mixture is hydrolysed over a mixture of ice/concentrated hydrochloric acid. The creamy white precipitate which forms is filtered off, washed several times with ice-cold water and dried over P2O5 using a dessicator. The title alcohol is recrystallised from a mixture of CH2Cl2/cyclohexane to yield white needles.
後処理
- additionare added with vigorous stirring
- additionthe reaction mixture is hydrolysed over a mixture of ice/concentrated hydrochloric acid
- filtrationThe creamy white precipitate which forms is filtered off
- washwashed several times with ice-cold water
- dry with materialdried over P2O5 using a dessicator
- customThe title alcohol is recrystallised from a mixture of CH2Cl2/cyclohexane
- customto yield white needles
出典と根拠
- ORDレコード
- ord-029cb000bdc8442e92e5896d1e60f42d
- 出典データセット
- uspto-grants-2003_06
- 特許番号
- US06583319B1
反応ノート
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