Methyl indole-7-carboxylate → 3-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indole-7-carboxylic acid methyl ester

HRID 13709

反応式

HRID 13709 の反応式
[CH2:1]([C:3]1(O)[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[CH3:14][O:15][C:16]([C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:26]=1[NH:25][CH:24]=[CH:23]2)=[O:17]>>[CH3:14][O:15][C:16]([C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:26]=1[NH:25][CH:24]=[C:23]2[C:3]1([CH2:1][CH3:2])[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1)=[O:17]

参加物

3

反応物 2

HCID 676694Methyl indole-7-carboxylateHCID 593404281-Ethyl-5-fluoroindan-1-ol

生成物 1

HCID 116024823-(1-Ethyl-5-fluoro-indan-1-yl)-1H-indole-7-carboxylic acid methyl ester

実験手順

Utilizing 1-ethyl-5-fluoro-indan-1-ol and 1H-indole-7-carboxylic acid methyl ester, the title compound is prepared as in example 1. 103 mg (75%). LC-MS m/z 338.1 (M++1).

出典と根拠

ORDレコード
ord-736cdd0e368242faa9ac6b54fa0a8699
出典データセット
uspto-grants-2010_06
特許番号
US07728150B2

関連ノート

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