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[2-Bromo-4-(bromomethyl)phenyl]methanol → 2-Bromo-4-(bromomethyl)benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | [2-Bromo-4-(bromomethyl)phenyl]methanol | HCID 12016037 | — |
| 触媒 | Manganese dioxide | HCID 14801 | — |
| 溶媒 | Ethanol ethylacetate | HCID 21584252 | — |
| 生成物 | 2-Bromo-4-(bromomethyl)benzaldehyde | HCID 12016038 | 80.6% |
反応手順
The compound of Step 2 (8 g, 29 mmol, 1 eq) was dissolved in 10% EtOH/EtOAc (300 ml) and 5 eq of MnO2 (12.4 g, 142 mmol) was added every hour for 6 hours. The mixture was filtered through Celite and solvent was removed. 6.5 g (80%) of the title compound was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06583126B2 |
| 出典データセット | uspto-grants-2003_06 |
| ORD ID | ord-ba1e10846eb5469a94855ddb2d8a532c |
| 出典メモ | uspto-grants-2003_06 |