Water → Guanine

HRID 1371278ノート

反応式

HRID 1371278 の反応式
[CH:1]1[NH:2][C:3]2[N:9]=[C:8]([NH2:10])[N:7]=[C:6](Cl)[C:4]=2[N:5]=1.C(N(CC)CC)C.C[O:20]C1C=C(C)C(S)=CC=1.O>CO>[NH:7]1[C:6](=[O:20])[C:4]2[NH:5][CH:1]=[N:2][C:3]=2[N:9]=[C:8]1[NH2:10]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 27595964-Methoxy-2-methylbenzenethiolHCID 1785084356-chloro-1H-purin-2-amine

生成物 1

HCID 135398634Guanine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6-Chloroguanine derivative prepared in Preparation 6 (4.86 g) was dissolved in 85 ml of methanol and 1.4 g of triethylamine and 2.9 g of 4-methoxythiocresol were added. The reaction mixture was reacted under reflux condition for 24 hours. The reaction was stopped by adding 20 ml of water, and the methanol was removed by distillation under reduced pressure. The reaction mixture was extracted with dichloromethane and purified by silica gel column to give a compound wherein 6-position of guanine was substituted by 4-methoxyphenylthio group.

後処理

  1. customThe reaction mixture was reacted
  2. temperatureunder reflux condition for 24 hours
  3. customthe methanol was removed by distillation under reduced pressure
  4. extractionThe reaction mixture was extracted with dichloromethane
  5. custompurified by silica gel column

出典と根拠

ORDレコード
ord-84d17f4f92b641489ef262c6b1c5cfc1
出典データセット
uspto-grants-2007_01
特許番号
US07157448B2

反応ノート

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