関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | 3,5-Dibromoimidazo[1,2-a]pyrazine | HCID 14207592 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 溶媒 | Isopropanol methylene chloride | HCID 21966342 | — |
| 生成物 | 2-[(3-Bromoimidazo[1,2-a]pyrazin-8-yl)amino]ethan-1-ol | HCID 21070904 | 33.5% |
反応手順
To a solution of 3,5-dibromo-imidazo[1,2-a]pyrazine (D) (400 mg, 1.44 mmol) in dioxane (2 ml) was added ethanolamine (0.436 ml, 7.22 mmol). The mixture was heated at 80° C. in sealed tube for 5 hr. The mixture was then cooled to rt, diluted with 20% IPA/DCM and water. The organic layer was washed with brine, dried and concentrated. The residue was purified on a silica gel column to give 124 mg (yield 33%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07157460B2 |
|---|
| 出典データセット | uspto-grants-2007_01 |
|---|
| ORD ID | ord-b955da5afce849edb86d9b8793128bff |
|---|
| 出典メモ | uspto-grants-2007_01 |
|---|
