tert-butyl 4-({[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}methyl)piperidine-1-carboxylate → HCID 69507286、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH:13][C:14]([NH:16][CH2:17][CH:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)=[O:15])[CH2:7]1>Cl.O1CCOCC1>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:31]=[CH:32][C:33]=1[Cl:34])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH:13][C:14]([NH:16][CH2:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[O:15])[CH2:7]1参加物
4
実験手順
Intermediate 17 (0.390 g) was stirred in 4.0M hydrogen chloride in dioxane (4 ml) for 2 h, at 23° C. under nitrogen. The solvent was removed in vacuo, azeotroped with dichloromethane (20 ml), and dried under vacuum to give the title compound as a pale yellow solid, (0.33 g).