2-Aminopropanol → 2-{[(3,4-Dichlorophenyl)methyl]amino}propan-1-ol

HRID 1371401ノート

反応式

HRID 1371401 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5]Cl.[NH2:11][CH:12]([CH3:15])[CH2:13][OH:14]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH:11][CH:12]([CH3:15])[CH2:13][OH:14]

参加物

3

反応物 2

HCID 51262-AminopropanolHCID 76093,4-Dichlorobenzyl chloride

生成物 1

HCID 219629772-{[(3,4-Dichlorophenyl)methyl]amino}propan-1-ol収率 79%

反応条件

温度
50 °C

実験手順

3,4-Dichlorobenzyl chloride (0.988 g) was added to 2-amino-1-propanol (4.10 g) and the mixture was stirred at 50° C. under nitrogen for 2 h. The mixture was partitioned between saturated aqueous sodium bicarbonate (100 ml) and ethyl acetate (100 ml) and the phases were separated. The organic layer was washed with water (4×100 ml) and brine, dried (Na2SO4) then concentrated under vacuum to give the title compound as a white solid (0.935 g).

後処理

  1. customThe mixture was partitioned between saturated aqueous sodium bicarbonate (100 ml) and ethyl acetate (100 ml)
  2. customthe phases were separated
  3. washThe organic layer was washed with water (4×100 ml) and brine
  4. dry with materialdried (Na2SO4)
  5. concentrationthen concentrated under vacuum

出典と根拠

ORDレコード
ord-fc91a1e74e0f49db8cc2e334f08fcc05
出典データセット
uspto-grants-2007_01
特許番号
US07157457B2

反応ノート

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