Benzene, 1-chloro-3-isocyanato- → N-(3-Chlorophenyl)-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea

HRID 1371413

反応式

HRID 1371413 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([N:25]=[C:26]=[O:27])[CH:20]=1>>[Cl:18][C:19]1[CH:20]=[C:21]([NH:25][C:26]([NH:13][CH2:12][CH:8]2[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]3[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:27])[CH:22]=[CH:23][CH:24]=1

参加物

3

反応物 2

HCID 17968Benzene, 1-chloro-3-isocyanato-HCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

生成物 1

HCID 10274205N-(3-Chlorophenyl)-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea

実験手順

Example 13 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 1-chloro-3-isocyanatobenzene (16.6 μl) to give the title compound (0.0247 g). LC-MS (System A): Rt 2.46 mins, Mass Spectrum m/z 428 [MH+].

後処理

  1. customExample 13 was prepared in an analogous manner to Example 1 using

出典と根拠

ORDレコード
ord-ee37355fc4f6429eb130bd652cdc9f51
出典データセット
uspto-grants-2007_01
特許番号
US07157457B2

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