4-Cyanophenyl isocyanate → N-(4-Cyanophenyl)-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea

HRID 1371424

反応式

HRID 1371424 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[Cl:17])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH2:13])[CH2:7]1.[N:18]([C:21]1[CH:28]=[CH:27][C:24]([C:25]#[N:26])=[CH:23][CH:22]=1)=[C:19]=[O:20]>>[C:25]([C:24]1[CH:23]=[CH:22][C:21]([NH:18][C:19]([NH:13][CH2:12][CH:8]2[O:9][CH2:10][CH2:11][N:6]([CH2:5][C:4]3[CH:14]=[CH:15][C:16]([Cl:17])=[C:2]([Cl:1])[CH:3]=3)[CH2:7]2)=[O:20])=[CH:28][CH:27]=1)#[N:26]

参加物

3

反応物 2

HCID 1703804-Cyanophenyl isocyanateHCID 10308229[4-(3,4-Dichlorobenzyl)morpholin-2-yl]methylamine

生成物 1

HCID 10136835N-(4-Cyanophenyl)-N'-{[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}urea収率 85.3%

実験手順

Example 25 was prepared in an analogous manner to Example 1 using a mixture of Intermediate 3 (0.025 g) and 4-isocyanatobenzonitrile (0.0196 g) to give the title compound (0.0325 g). LC-MS (System A): Rt 2.29 mins, Mass Spectrum m/z 419 [MH+].

後処理

  1. customExample 25 was prepared in an analogous manner to Example 1 using

出典と根拠

ORDレコード
ord-a89a76d8a64048c4977c8645b0c18244
出典データセット
uspto-grants-2007_01
特許番号
US07157457B2

関連ノート

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