Isobutylamine → HCID 178449179、化合物
反応式
[NH2:1][C:2]1[C:3]([C:7]#[N:8])=[N:4][O:5][N:6]=1.[CH2:9]([NH2:13])[CH:10]([CH3:12])[CH3:11].[Al+3].[Cl-].[Cl-].[Cl-]>ClC(Cl)C>[NH2:1][C:2]1[C:3]([C:7]([NH:13][CH2:9][CH:10]([CH3:12])[CH3:11])=[NH:8])=[N:4][O:5][N:6]=1参加物
5
実験手順
To a solution of 4-amino-1,2,5-oxadiazole-3-carbonitrile (220 mg, 2 mmol) and isobutylamine (0.2 mL, 2 mmol) in dichloroethane (1 mL) was added AlCl3 (293 mg, 2.2 mmol). The reaction mixture is stirred for 20 min and then quenched with ice cold water (5 mL). The mixture is extracted with diethyl ether (3×20 mL). Combined extracts was dried over anhydrous Na2SO4 and concentrated under vacuum to afford the title compound as a white solid. MS 184 M+1. The crude product was carried to next step without further purification.
後処理
- customquenched with ice cold water (5 mL)
- extractionThe mixture is extracted with diethyl ether (3×20 mL)
- dry with materialCombined extracts was dried over anhydrous Na2SO4
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-de97819fe603475ba62361996a85d2a3
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157476B2
反応ノート
読み込み中…