Toluene → 2-Bromo-1-(4-(2-methylpropyl)phenyl)ethan-1-one

HRID 1371582

反応式

HRID 1371582 の反応式
[Br:1]Br.[CH2:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=1)[CH:4]([CH3:6])[CH3:5].C1(C)C=CC=CC=1>C(O)C>[Br:1][CH2:14][C:13]([C:10]1[CH:9]=[CH:8][C:7]([CH2:3][CH:4]([CH3:6])[CH3:5])=[CH:12][CH:11]=1)=[O:15]

参加物

5

反応物 3

HCID 1140TolueneHCID 24408BromineHCID 932144'-Isobutylacetophenone

生成物 1

HCID 136563372-Bromo-1-(4-(2-methylpropyl)phenyl)ethan-1-one収率 57%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
5 °C

実験手順

Bromine (1.25 ml; 25 mmol) is added dropwise to a solution of 4′-isobutylacetophenone (3.52 g; 20 mmol) in 60 ml of ethanol cooled down to approximately 5° C. After stirring the reaction mixture for 30 minutes at this temperature, stirring is continued for one hour at ambient temperature. The reaction medium, to which small portions of toluene are added, is concentrated to dryness. After purification on a silica column (eluent: ethyl-heptane acetate: 5-95), a colourless oil is obtained with a yield of 57%.

後処理

  1. stirringstirring
  2. waitis continued for one hour at ambient temperature
  3. concentrationis concentrated to dryness
  4. customAfter purification on a silica column (eluent: ethyl-heptane acetate: 5-95)
  5. customa colourless oil is obtained with a yield of 57%

出典と根拠

ORDレコード
ord-7398c5eda51b4ea1b0fa72aaeaa39b1f
出典データセット
uspto-grants-2007_01
特許番号
US07157483B2

関連ノート

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