(4-Amino-2-ethanesulfonyl-pyrimidin-5-yl)-(5-fluoro-2-methoxy-phenyl)-methanone → 3-[4-[4-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyrimidin-2-ylamino]-phenoxy]-piperidine-1-carboxylic acid ethyl ester
反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([O:14][C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=2)[CH2:9]1)=[O:7])([CH3:4])(C)C.[NH2:22][C:23]1[C:28]([C:29]([C:31]2[CH:36]=[C:35]([F:37])[CH:34]=[CH:33][C:32]=2[O:38][CH3:39])=[O:30])=[CH:27][N:26]=[C:25](S(CC)(=O)=O)[N:24]=1>>[CH2:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([O:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:25]3[N:24]=[C:23]([NH2:22])[C:28]([C:29](=[O:30])[C:31]4[CH:36]=[C:35]([F:37])[CH:34]=[CH:33][C:32]=4[O:38][CH3:39])=[CH:27][N:26]=3)=[CH:17][CH:16]=2)[CH2:9]1)=[O:7])[CH3:4]参加物
3
実験手順
3-(4-Amino-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester ((prepared as described above in Example 139) and the compound of Example 48 were treated as in Example 113, the resulting product was then treated as in Example 114, and then as in Example 115 to give 3-[4-[4-amino-5-(5-fluoro-2-methoxy-benzoyl)-pyrimidin-2-ylamino]-phenoxy]-piperidine-1-carboxylic acid ethyl ester. MS(ES) (M+H)+=510.