1,2,3-Trifluoro-5-methoxybenzene → (4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,3,4-trifluoro-6-methoxy-phenyl)-methanone

反応式

CON(C)[C:4]([C:6]1[C:7]([NH2:15])=[N:8][C:9]([S:12][CH2:13][CH3:14])=[N:10][CH:11]=1)=[O:5].[F:17][C:18]1[CH:19]=[C:20]([O:26][CH3:27])[CH:21]=[C:22]([F:25])[C:23]=1[F:24]>>[NH2:15][C:7]1[C:6]([C:4]([C:19]2[C:20]([O:26][CH3:27])=[CH:21][C:22]([F:25])=[C:23]([F:24])[C:18]=2[F:17])=[O:5])=[CH:11][N:10]=[C:9]([S:12][CH2:13][CH3:14])[N:8]=1

参加物

反応物 2

HCID 27769461,2,3-Trifluoro-5-methoxybenzene

HCID 119748325-Pyrimidinecarboxamide, 4-amino-2-(ethylthio)-N-methoxy-N-methyl-

生成物 1

HCID 11975325(4-Amino-2-ethylsulfanyl-pyrimidin-5-yl)-(2,3,4-trifluoro-6-methoxy-phenyl)-methanone

実験手順

The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 3,4,5-trifluoroanisole (Aldrich) in an analogous manner as described in Example 169.

出典と根拠

ORDレコード: ord-ad66638830ad4271ae3dc997ed33d15b
出典データセット: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07157455B2

反応ノート

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