[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → HCID 58777551、化合物

反応式

[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[C:14]([O:18][CH3:19])[CH:13]=[C:12]([F:20])[C:11]=2[F:21])=[O:9])=[CH:6][N:5]=[C:4](S(C)=O)[N:3]=1.FC(F)(F)C(O)=O.[CH3:32][S:33]([N:36]1[CH2:41][CH2:40][CH:39]([NH2:42])[CH2:38][CH2:37]1)(=[O:35])=[O:34]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([O:16][CH3:17])=[C:14]([O:18][CH3:19])[CH:13]=[C:12]([F:20])[C:11]=2[F:21])=[O:9])=[CH:6][N:5]=[C:4]([NH:42][CH:39]2[CH2:40][CH2:41][N:36]([S:33]([CH3:32])(=[O:35])=[O:34])[CH2:37][CH2:38]2)[N:3]=1

参加物

反応物 2

HCID 11975076[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate

HCID 21070613HCID 21070613、化合物

生成物 1

HCID 58777551HCID 58777551、化合物

実験手順

The compound was prepared from (4-amino-2-methylsulfinyl-pyrimidin-5-yl)-(2,3-difluoro-5,6-dimethoxy-phenyl)-methanone (Example 260) and 1-methanesulfonyl-piperidin-4-ylamine; compound with trifluoroacetic acid (Example 162) in an analogous manner as described in Example 172. HR-MS (ES, m/z) calculated for C19H24N5O5SF [(M+H)+] 472.1465, observed 472.1461.

出典と根拠

ORDレコード: ord-34538f74f1124117851fd764a929f8b2
出典データセット: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07157455B2

反応ノート

読み込み中…