Hydrochloric Acid → 2-oxo-2-(5-phenoxy-1H-indol-3-yl)acetamide

HRID 1371892ノート

反応式

HRID 1371892 の反応式
[O:1]=[C:2]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:13]=2)[NH:8][CH:7]=1)[C:3](Cl)=[O:4].[OH-].[NH4+:23].Cl>>[O:1]=[C:2]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:13]=2)[NH:8][CH:7]=1)[C:3]([NH2:23])=[O:4]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14923Ammonium HydroxideHCID 210714422-Oxo-(5-phenoxy-1H-indol-3-yl)acetyl chloride

生成物 1

HCID 210714372-oxo-2-(5-phenoxy-1H-indol-3-yl)acetamide収率 96.4%

実験手順

Combine 2-oxo-(5-phenoxy-1H-indol-3-yl)acetyl chloride (2.15 g, 7.18 mmol), and ammonium hydroxide (28–30%, 32 ml, 680 mmol) and stir for 2 hours. Pour the reaction mixture into 10% (aq.) HCl, extract with dichloromethane, combine the organic layers and dry over Na2SO4, evaporate solvent in vacuo to give 1.94 g (96%) of title compound: 1H NMR (300 MHz, CDCl3) 4.87 (s, 2H), 7.51–7.91 (m, 7H), 8.13–8.24 (m, 3H).

後処理

  1. extractionextract with dichloromethane
  2. dry with materialdry over Na2SO4
  3. customevaporate solvent in vacuo

出典と根拠

ORDレコード
ord-4fa060e2b2934bb785e647f78f87012a
出典データセット
uspto-grants-2007_01
特許番号
US07157488B2

反応ノート

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