Hydrazine → 5-ethyl-3-(trifluoromethyl)-1H-pyrazole
反応式
[F:1][C:2]([F:11])([F:10])[C:3](=O)[CH2:4][C:5](=O)[CH2:6][CH3:7].[NH2:12][NH2:13]>C(O)C>[CH2:6]([C:5]1[NH:13][N:12]=[C:3]([C:2]([F:11])([F:10])[F:1])[CH:4]=1)[CH3:7]参加物
4
実験手順
To a solution of 1,1,1-Trifluoro-hexane-2,4-dione (1 g, 5.95 mmol) in absolute ethanol (10 mL) was added NH2NH2.xH2O drop-wise at 0° C. The reaction mixture warmed to the room temperature during 1 hour and refluxed overnight. Ethanol was then evaporated, residue dissolved in ethyl acetate (20 mL), washed consecutively with saturated brine solution and water, dried with Na2SO4 and concentrated to give the title compound as colorless oil.
後処理
- customat 0° C
- temperaturerefluxed overnight
- customEthanol was then evaporated
- dissolutionresidue dissolved in ethyl acetate (20 mL)
- washwashed consecutively with saturated brine solution and water
- dry with materialdried with Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-81688da026a44ce7882e623d55ee89df
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157464B2
反応ノート
読み込み中…