化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 1-(3,5-Difluoropyridin-2-yl)methanamine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Cyano-3,5-difluoropyridine | HCID 2783253 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Tetrahydrofuran ethanol | HCID 21873804 | — |
| 生成物 | 1-(3,5-Difluoropyridin-2-yl)methanamine hydrochloride | HCID 21069853 | 100% |
反応手順
A mixture of 3,5-difluoropicolinonitrile (1.4 g, 10 mmol), conc.HCl (12 ml) and 10% Pd—C (200 mg) in 1:1 ethanol/tetrahydrofuran was shaken under a hydrogen atmosphere (50 psi) for 5 h. The reaction mixture was filtered and the ethanol removed in vacuo. The remaining solution was lyophilized to afford an off-white solid (2.16 g, 100% yield). LCMS (M+H) calcd for C6H7F2N2: 145.06. found: 145.12.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07157447B2 |
| 出典データセット | uspto-grants-2007_01 |
| ORD ID | ord-5a4e999dfdc745588a16416be98a9c54 |
| 出典メモ | uspto-grants-2007_01 |