Ammonia → HCID 20241990、化合物
反応式
[NH3:1].[ClH:2].[I:3][C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][CH:14]=1)[C:7](=[NH:11])OCC>C(O)C>[ClH:2].[I:3][C:4]1[CH:5]=[C:6]([CH:12]=[CH:13][CH:14]=1)[C:7]([NH2:11])=[NH:1]参加物
4
実験手順
Ammonia gas was bubbled into an ice-cold suspension of the product (1.00 g, 3.21 mmol) from Step A in 20 mL of absolute ethanol for 20 min. The resultant clear solution was allowed to warm to room temperature and stirred for 48 h. The reaction mixture was then concentrated under reduced pressure, and the residue was triturated with diethyl ether. The supernatant was decanted, and the residual gummy product was dried in vacuo to afford the title compound as white foam.
後処理
- concentrationThe reaction mixture was then concentrated under reduced pressure
- customthe residue was triturated with diethyl ether
- customThe supernatant was decanted
- customthe residual gummy product was dried in vacuo
出典と根拠
- ORDレコード
- ord-0db41156346b41e385a9917975453e08
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157490B2
反応ノート
読み込み中…