2-Amino-5-bromopyridine → N'-(5-Bromopyridin-2-yl)-N,N-dimethylformimidamide
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>CN(C)C=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]=[CH:11][N:12]([CH3:14])[CH3:13])=[N:6][CH:7]=1参加物
4
反応条件
- 温度
- 130 °C
実験手順
To a stirred solution of 5-bromo-2-aminopyridine (3.0 g, 17.3 mmol) in N,N-dimethylformamide (6 mL) was added N,N-dimethylformamide dimethyl acetal (5.37 g, 45.0 mmol). The reaction mixture was heated to 130° C. overnight. After cooling to room temperature, the volatiles were removed under reduced pressure to afford the desired product as a brown oil. LC/MS 227.8 (M+1)
後処理
- temperatureAfter cooling to room temperature
- customthe volatiles were removed under reduced pressure
出典と根拠
- ORDレコード
- ord-a33dca15574b492b92aac01dada5ac40
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07157490B2
反応ノート
読み込み中…