Ethyl Acetoacetate → 2-(3,4-Dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one

HRID 1372829

反応式

HRID 1372829 の反応式
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([NH:10][NH2:11])[CH:6]=[CH:7][C:8]=1[CH3:9].[C:12](OCC)(=[O:17])[CH2:13][C:14]([CH3:16])=O.C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:2][C:3]1[CH:4]=[C:5]([N:10]2[C:12](=[O:17])[CH:13]=[C:14]([CH3:16])[NH:11]2)[CH:6]=[CH:7][C:8]=1[CH3:9]

参加物

5

反応物 3

HCID 8868Ethyl AcetoacetateHCID 1737401-(3,4-Dimethylphenyl)hydrazine hydrochlorideHCID 517045Sodium Acetate

生成物 1

HCID 117358292-(3,4-Dimethylphenyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 3,4-dimethylphenylhydrazine hydrochloride (17.7 g; 0.1 mol.), ethyl acetoacetate (13.0 g; 0.1 mol.) and sodium acetate (8.2 g; 0.1 mol.) in glacial acetic acid; (250 mL) was stirred and heated under reflux for 24 h.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 24 h.

出典と根拠

ORDレコード
ord-23628097b02d4c7785b65863c79b4bb1
出典データセット
uspto-grants-2007_01
特許番号
US07160870B2

関連ノート

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