tert-butyl N-(2-methyl-4-oxobutan-2-yl)carbamate → Tert-butyl {3-[2-(1-hydroxycyclohexyl)phenylamino]-1,1-dimethylpropyl}carbamate
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1([OH:14])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[CH3:15][C:16]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:20])[CH2:17][CH:18]=O>CCCCCC.CCOC(C)=O>[OH:14][C:8]1([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][CH2:18][CH2:17][C:16]([NH:21][C:22](=[O:28])[O:23][C:24]([CH3:27])([CH3:26])[CH3:25])([CH3:20])[CH3:15])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1参加物
4
実験手順
The product is prepared analogously to intermediate product 1b starting from 1-(2-amino-phenyl)-cyclohexanol and tert-butyl (1,1-dimethyl-3-oxo-propyl)-carbamate. After column chromatography (silica gel, hexane/EtOAc 7:1) the product is obtained as a colourless oil. Yield: 2.65 g (66%); Rf=0.50 (silica gel, hexane/EtOAc 4:1).