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Lithium Hydroxide → Succinanilic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | Succinamide | HCID 8036 | — |
| 反応物 | Methyl 4-chloroacetoacetate | HCID 36240 | — |
| 反応物 | 2-(Phenylcarbamoyl)acetic acid | HCID 256593 | — |
| 生成物 | Succinanilic acid | HCID 7598 | — |
反応手順
The synthesis of the succinamide analogs 29, 30, 31, 32, and 33 are described in Schemes 12, 13, and 14. N-Phenyl-succinamic acid was prepared via a two step reaction sequence analogous to the preparation of the N-phenyl-malonamic acid: 1) reaction of aniline with methyl 4-chloro-3-oxobutyrate followed by 2) treatment with lithium hydroxide. Coupling of N-phenyl-succinamic acid with 1-(2-methylamino-(S)-2-phenyl-ethyl)-pyrrolidin-(S)-3-ol, 1-(3-methyl-(S)-2-methylamino-butyl)-pyrrolidin-(S)-3-ol or 1-piperidin-(S)-2-ylmethyl-pyrrolidin-(S)-3-ol afforded 29, 30 and 31, respectively.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07160902B2 |
| 出典データセット | uspto-grants-2007_01 |
| ORD ID | ord-af277b7469404150b416483520c15498 |
| 出典メモ | uspto-grants-2007_01 |