化工社化工社 化学情報印刷レポート · 研究参考用
Aniline → Methyl 4-anilino-4-oxobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | Succinamide | HCID 8036 | — |
| 反応物 | Methyl 4-chloroacetoacetate | HCID 36240 | — |
| 反応物 | Methyl malonyl chloride | HCID 123460 | — |
| 生成物 | Methyl 4-anilino-4-oxobutanoate | HCID 224712 | — |
反応手順
Using the same reaction conditions as described in Example 20-step a except that methyl 4-chloro-3-oxobutyrate replaced methyl 3-chloro-3-oxopropionate, aniline (2.33 g, 25 mmol) was converted to the succinamide compound (5.18 g, 100%) after purification by chromatography over silica gel. 1H NMR (400 MHz, CDCl3) δ: 7.70 (s, 1H), 7.50 (d, 2H), 7.30 (t, 2H), 7.09 (m, 1H), 3.70 (s, 3H), 2.73–2.65 (m, 4H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07160902B2 |
| 出典データセット | uspto-grants-2007_01 |
| ORD ID | ord-4177852deba4418f910d698c6c4a5d57 |
| 出典メモ | uspto-grants-2007_01 |