Water → N-[2-(dimethylamino)ethyl]benzenesulfonamide

HRID 1373120ノート

反応式

HRID 1373120 の反応式
[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][NH2:5].C(N(CC)CC)C.[C:14]1([S:20](Cl)(=[O:22])=[O:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.O>ClCCl>[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][NH:5][S:20]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:22])=[O:21]

参加物

6

反応物 4

HCID 962WaterHCID 7369Benzenesulfonyl chlorideHCID 8471TriethylamineHCID 66053N,N-Dimethylethylenediamine

生成物 1

HCID 2478570N-[2-(dimethylamino)ethyl]benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2.8 g (30 mmol) of N,N-dimethylethylenediamine are placed in 100 ml of dichloromethane and 8.3 ml (60 mmol) of triethylamine. While cooling with ice a solution of 3.9 ml (30 mmol) of benzenesulphonic acid chloride in 100 ml of dichloromethane is added dropwise and the mixture is stirred overnight at ambient temperature. Water is added and the mixture is extracted with dichloromethane. The organic phase is dried and evaporated down.

後処理

  1. additionis added dropwise
  2. extractionthe mixture is extracted with dichloromethane
  3. customThe organic phase is dried
  4. customevaporated down

出典と根拠

ORDレコード
ord-9340ad6b2c154970a0176672e48eda37
出典データセット
uspto-grants-2007_01
特許番号
US07160901B2

反応ノート

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