化工社化工社 化学情報印刷レポート · 研究参考用
1-Acetyl-5-nitroindolin-2-one → 1-Acetyl-5-aminoindolin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Acetyl-5-nitroindolin-2-one | HCID 2839329 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Acetyl-5-aminoindolin-2-one | HCID 12046998 | — |
反応手順
30.0 g (136 mmol) of 1-acetyl-5-nitro-2-indolinone are dissolved in a mixture of 650 ml of dichloromethane and 650 ml of methanol and after the addition of 5 g of 10% palladium on activated charcoal the mixture is hydrogenated for 45 minutes with hydrogen. Then the catalyst is filtered off and evaporated down.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07160901B2 |
| 出典データセット | uspto-grants-2007_01 |
| ORD ID | ord-20d1f7e55882484bb6b38a2f3b1021d2 |
| 出典メモ | uspto-grants-2007_01 |