Tert-butyl[3-(5-benzyloxy-2-nitrophenoxy)benzyl]carbamate → Tert-butyl[3-(2-amino-5-hydroxyphenoxy)benzyl]carbamate

HRID 1373220ノート

反応式

HRID 1373220 の反応式
[C:1]([O:5][C:6](=[O:33])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][C:16]2[CH:21]=[C:20]([O:22]CC3C=CC=CC=3)[CH:19]=[CH:18][C:17]=2[N+:30]([O-])=O)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2]>[C].[Pd].C(OCC)(=O)C>[C:1]([O:5][C:6](=[O:33])[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][C:16]2[CH:21]=[C:20]([OH:22])[CH:19]=[CH:18][C:17]=2[NH2:30])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 21073109Tert-butyl[3-(5-benzyloxy-2-nitrophenoxy)benzyl]carbamate

生成物 1

HCID 21073107Tert-butyl[3-(2-amino-5-hydroxyphenoxy)benzyl]carbamate収率 98.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

5% carbon-palladium (3.2 g) was added to an ethyl acetate (300 ml) solution of tert-butyl[3-(5-benzyloxy-2-nitrophenoxy)benzyl]carbamate (10.5 g, 23.3 mmols). The resulting mixture was hydrogenated at room temperature under atmospheric pressure. The catalyst was removed through filtration, and the filtrate was concentrated under reduced pressure to give a brown oil of tert-butyl[3-(2-amino-5-hydroxyphenoxy)benzyl]carbamate (7.6 g, 98.8%).

後処理

  1. customwas hydrogenated at room temperature under atmospheric pressure
  2. customThe catalyst was removed through filtration
  3. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8594ec69f87943be9b2f8a795fea13fc
出典データセット
uspto-grants-2007_01
特許番号
US07160887B1

反応ノート

読み込み中…