1-(5,6,7,8-Tetrahydronaphthalen-1-yl)piperazine → 5-Methyl-7-{4-[4-(5,6,7,8-tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-[1,8]naphthyridin-2-one

HRID 1373612

反応式

HRID 1373612 の反応式
[CH3:1][C:2]1[C:11]2[CH2:10][CH2:9][C:8](=[O:12])[NH:7][C:6]=2[N:5]=[C:4]([O:13][CH2:14][CH2:15][CH2:16][CH:17]=O)[CH:3]=1.[C:19]1([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[C:28]2[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=2[CH:22]=[CH:21][CH:20]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][N:32]2[CH2:31][CH2:30][N:29]([C:19]3[C:28]4[CH2:27][CH2:26][CH2:25][CH2:24][C:23]=4[CH:22]=[CH:21][CH:20]=3)[CH2:34][CH2:33]2)[N:5]=[C:6]2[C:11]=1[CH2:10][CH2:9][C:8](=[O:12])[NH:7]2

参加物

3

反応物 2

HCID 986981-(5,6,7,8-Tetrahydronaphthalen-1-yl)piperazineHCID 210733504-(4-Methyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde

生成物 1

HCID 210734215-Methyl-7-{4-[4-(5,6,7,8-tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-butoxy}-3,4-dihydro-1H-[1,8]naphthyridin-2-one

実験手順

The title compound was prepared by reductive amination of 4-(4-methyl-7-oxo-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde with 1-(5,6,7,8-tetrahydro-naphthalen-1-yl)-piperazine according to the above procedure. MS: APCI: M+1: 450.0 (Exact Mass: 448.28).

出典と根拠

ORDレコード
ord-a05f6472d8fa4baeab359f3e06a2916c
出典データセット
uspto-grants-2007_01
特許番号
US07160888B2

関連ノート

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