1-(5,6,7,8-Tetrahydronaphthalen-1-yl)piperazine → 7-{4-[4-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-butoxy}-5-trifluoromethyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

関与物質

反応手順

In a manner similar to that of other examples above, 1-(5,6,7,8-tetrahydro-naphthalen-1-yl)-piperazine was coupled by reductive amination to 4-(7-oxo-4-trifluoromethyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 503.1 (Exact Mass: 502.26).

情報源と証拠