Triethylamine → 2-(Allyloxy)-5-bromo-3-fluoroaniline
反応式
[CH2:1]([O:4][C:5]1[C:10]([N+:11]([O-])=O)=[CH:9][C:8]([Br:14])=[CH:7][C:6]=1[F:15])[CH:2]=[CH2:3].O.O.[Sn](Cl)(Cl)(Cl)Cl.C(N(CC)CC)C>C(O)C>[CH2:1]([O:4][C:5]1[C:6]([F:15])=[CH:7][C:8]([Br:14])=[CH:9][C:10]=1[NH2:11])[CH:2]=[CH2:3]参加物
5
実験手順
A mixture of Example 89A (1.3 g, 4.71 mmol), tin chloride dihydrate (5.3 g, 23.5 mmol) and triethylamine (13.1 mL, 94.2 mmol) in ethanol (50 mL) was heated at 70° C. for 6 hours, cooled. The insoluble material was filtered off and extensively washed with ethyl acetate. The combined filtrate was concentrated, and the residue was purified by flash chromatography eluting with 5% ethyl acetate in dichloromethane to provide the desired product (638 mg, 55%). MS (DCI/NH3) m/z 247.82 (M+H)+; 1H NMR (500 MHz, DMSO-D6) δ ppm 4.41 (d, J=5.93 Hz, 2 H) 5.20 (dd, J=10.45, 1.72 Hz, 1 H) 5.30 (dd, J=17.31, 1.72 Hz, 1 H) 5.43 (s, 2 H) 6.03 (m, 1 H) 6.56 (dd, J=10.29, 2.50 Hz, 1 H) 6.66 (dd, J=2.34, 1.72 Hz, 1 H).