Hydrochloric Acid → HCID 21075719、化合物
反応式
[CH3:1][C:2]1[N:3]([NH:15]C(=O)OC(C)(C)C)[C:4]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]=[CH:6][C:5]=2[N:14]=1.[ClH:23]>CCO>[ClH:23].[CH3:1][C:2]1[N:3]([NH2:15])[C:4]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:7]=[CH:6][C:5]=2[N:14]=1参加物
4
実験手順
tert-Butyl N-(2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)carbamate (5.00 g, 16.8 mmol) was dissolved in 40 mL of 1.65 M HCl in EtOH, and the reaction mixture was heated to reflux for 2 h. The reaction mixture was cooled and concentrated under reduced pressure to give a brown solid. The brown solid was crystallized from ethanol/H2O to give 3.13 g of 2-methyl-1H-imidazo[4,5-c]quinolin-1-amine hydrochloride.
後処理
- temperaturethe reaction mixture was heated
- temperatureto reflux for 2 h
- temperatureThe reaction mixture was cooled
- concentrationconcentrated under reduced pressure
- customto give a brown solid
- customThe brown solid was crystallized from ethanol/H2O
出典と根拠
- ORDレコード
- ord-91ac0797ff004471b6af52cdb8cc37aa
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07163947B2
反応ノート
読み込み中…