Hydrogen Peroxide → 2-tert-Butyl-1-oxo-1lambda~5~-pyridinato

HRID 1374244ノート

反応式

HRID 1374244 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:11]O>CC(O)=O.C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:11])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 784Hydrogen PeroxideHCID 1386302-tert-Butylpyridine

生成物 1

HCID 187150642-tert-Butyl-1-oxo-1lambda~5~-pyridinato収率 71.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

Preparation C3, Step 1: 2-tert-butylpyridine (2.00 g, 14.8 mmol, 1 eq.) was dissolved in HOAc (10 mL) and 30% hydrogen peroxide (1.68 mL, 14.8 mmol, 1 eq.) at room temperature then the reaction was refluxed for 20 hours. The reaction was stripped to obtain an amber oil which was dissolved in methylene chloride (10 mL) then dried over sodium sulfate and stripped to obtain 2-tert-butylpyridine-N-oxide (1.60 g) as an amber oil. Yield=71.5%. LCMS detects (M+H)+=152.09.

後処理

  1. customto obtain an amber oil which
  2. dry with materialthen dried over sodium sulfate

出典と根拠

ORDレコード
ord-51fc4c6ac0ba46bd9f7bff9ec20eb53f
出典データセット
uspto-grants-2007_01
特許番号
US07163937B2

反応ノート

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