化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylcarbamoyl Chloride → 4-Pentyl-2-cyanopyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| 反応物 | Trimethylsilyl cyanide | HCID 82115 | — |
| 反応物 | 4-(Benzyloxy)pyridine N-oxide | HCID 295871 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Pentyl-2-cyanopyridine | HCID 21076083 | 100% |
反応手順
To trimethylsilyl cyanide (5.2 g, 52 mmol), 4-benzyloxy-pyridine 1-oxide (8.8 g, 44 mmol) in DCM (20 mL) was added, followed by dimethylcarbamoyl chloride (5.6 g, 52 mmol) in DCM (10 mL), dropwise, stirred at room temperature overnight. Sodium bicarbonate (100 mL, 10%) was added, stirred for 10 minutes and extracted twice with DCM (50 mL). The combined organic layer was dried over magnesium sulfate, solvent was removed to obtain the product, compound 10a (R9=Benzyloxy) (10.5 g, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07164011B2 |
| 出典データセット | uspto-grants-2007_01 |
| ORD ID | ord-8ff36099531048408abe54de9026d0ee |
| 出典メモ | uspto-grants-2007_01 |