関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Glutaric anhydride | HCID 7940 | — |
| 反応物 | 1-(3-Chloropropyl)piperazine | HCID 577606 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 5-[4-(3-Chloropropyl)piperazin-1-yl]-5-oxopentanoic acid | HCID 18521565 | 103.5% |
反応手順
1.5 g of glutaric anhydride and then 2.13 g of N-(chloropropyl)piperazine in solution in 5 cm3 of dioxane and 1 cm3 of dichloromethane are added to 15 cm3 of dioxane in a round-bottomed flask kept under an argon atmosphere. After stirring for 2 hours at 20° C., the solvent is evaporated under reduced pressure (2.7 kPa) at 20° C., to give 3.75 g of 5-[4-(3-chloropropyl)piperazin-1-yl]-5-oxopentanoic acid in the form of a yellow oil which is used as it is.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07166594B2 |
|---|
| 出典データセット | uspto-grants-2007_01 |
|---|
| ORD ID | ord-96c1dc858ff74f3cb896a2f09e7f95e7 |
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| 出典メモ | uspto-grants-2007_01 |
|---|
