Water → 5-Fluoro-2-(trifluoromethyl)phenylacetonitrile

HRID 1374626ノート

反応式

HRID 1374626 の反応式
[C-:1]#[N:2].[K+].[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:13]([F:16])([F:15])[F:14])=[C:9]([CH:12]=1)[CH2:10]Br.O>C(O)C.C(OCC)(=O)C>[F:4][C:5]1[CH:6]=[CH:7][C:8]([C:13]([F:16])([F:15])[F:14])=[C:9]([CH2:10][C:1]#[N:2])[CH:12]=1

参加物

6

反応物 3

HCID 962WaterHCID 9032Potassium CyanideHCID 27375785-Fluoro-2-(trifluoromethyl)benzyl bromide

生成物 1

HCID 27376045-Fluoro-2-(trifluoromethyl)phenylacetonitrile

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

1.95 g (30 mmol) of potassium cyanide is added to a solution of 5.14 g (20 mmol) of 5-fluoro-2-trifluoromethylbenzyl bromide in 45 ml of ethanol/8 ml of water, and it is stirred for 64 hours at room temperature. The reaction solution is diluted with ethyl acetate and extracted with saturated sodium bicarbonate solution. The organic phase is washed with water, dried and concentrated by evaporation. The remaining residue is purified by bulb tube distillation and recrystallized. Yield: 3.6 g (89%).

後処理

  1. extractionextracted with saturated sodium bicarbonate solution
  2. washThe organic phase is washed with water
  3. customdried
  4. concentrationconcentrated by evaporation
  5. customThe remaining residue is purified by bulb tube
  6. distillationdistillation
  7. customrecrystallized

出典と根拠

ORDレコード
ord-2f81eee98c95417489e7276c8f592b6a
出典データセット
uspto-grants-2007_01
特許番号
US07166592B2

反応ノート

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