Ethyl 2-(4-cyanophenyl)acetate → Ethyl 2-(4-(aminomethyl)phenyl)acetate

HRID 1374733ノート

反応式

HRID 1374733 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][CH:4]=1)#[N:2]>N.[Ni]>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][CH:4]=1

参加物

4

反応物 1

HCID 279718Ethyl 2-(4-cyanophenyl)acetate

生成物 1

HCID 11535728Ethyl 2-(4-(aminomethyl)phenyl)acetate

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 222Ammonia溶媒

実験手順

0.5 g (2.6 mmol) of ethyl (4-cyanophenyl)acetate was dissolved in 70 ml of ethanolic ammonia solution and hydrogenated, at room temperature and under standard pressure, over Raney nickel. After 45 minutes, the mixture was filtered and evaporated. This resulted in 0.42 g (82%) of ethyl (4-aminomethylphenyl)acetate. MS (ES+): m/e=194.11

後処理

  1. filtrationthe mixture was filtered
  2. customevaporated
  3. customThis resulted in 0.42 g (82%) of ethyl (4-aminomethylphenyl)acetate

出典と根拠

ORDレコード
ord-c29348e54dc74efa97f6cfaf37f94093
出典データセット
uspto-grants-2007_01
特許番号
US07166609B2

反応ノート

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