4-(Aminomethyl)piperidine → tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)

HRID 1374828ノート

反応式

HRID 1374828 の反応式
NCC1CCNCC1.[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1.C(OCC)(=O)C.[ClH:30]>C(OCC)(=O)C>[ClH:30].[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1

参加物

5

反応物 3

HCID 235274-(Aminomethyl)piperidineHCID 7368171-Boc-4-(aminomethyl)piperidineHCID 21866389Hydrogen chloride-ethyl acetate

生成物 1

HCID 2756034tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)収率 82%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

By using 4-aminomethylpiperidine 5.71 g as a starting material, tert-butyl 4-aminomethylpiperidine-1-carboxylate was prepared according to the method described in Synthetic Commun., 22(16), 2357–2360 (1992). The resulting compound was dissolved in 80 ml of ethyl acetate, and the solution was added with 4N hydrogen chloride-ethyl acetate and stirred. The precipitated solids were collected by filtration to obtain the title compound (10.27 g, yield: 82%).

後処理

  1. customwas prepared
  2. filtrationThe precipitated solids were collected by filtration

出典と根拠

ORDレコード
ord-2ddb96259e7d41479389f7fbc4da843d
出典データセット
uspto-grants-2007_01
特許番号
US07166617B2

反応ノート

読み込み中…