Acetone → 1937215-88-7

HRID 1374854ノート

反応式

HRID 1374854 の反応式
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:28])[CH2:10][N:11]2[CH2:16][CH2:15][CH:14]([CH2:17][N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:19]3=[O:27])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1.O.CC(C)=[O:32]>C(OCC)(=O)C>[OH2:27].[OH2:32].[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:28])[CH2:10][N:11]2[CH2:12][CH2:13][CH:14]([CH2:17][N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[C:19]3=[O:27])[CH2:15][CH2:16]2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 180AcetoneHCID 962WaterHCID 21078079359625-80-22 回

生成物 1

HCID 210780801937215-88-7収率 79%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
60 °C

実験手順

2-[[1-[2-(4-Fluorophenyl)-2-oxoethyl]piperidin-4-yl]methyl]isoindolin-1-one hydrochloride (the compound of Example 1, 39.4 mmol) was added to water (30 mL) and acetone (210 mL), and mixture was heated at 60° C. for dissolution. The mixture was added dropwise with ethyl acetate (100 mL) and stand for cooling to room temperature. The crystals precipitated were collected by filtration and the resulting crystals were washed with ethyl acetate and dried under reduced pressure to obtain the title compound (yield: 79%).

後処理

  1. temperaturefor cooling to room temperature
  2. customThe crystals precipitated
  3. filtrationwere collected by filtration
  4. washthe resulting crystals were washed with ethyl acetate
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-fb872da5c1e5452ab3504350e2f68b5d
出典データセット
uspto-grants-2007_01
特許番号
US07166617B2

反応ノート

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