Acetic Acid → HCID 10473045、化合物
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=O)[C:9]2=[O:18])=[CH:4][CH:3]=1.[F:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([F:27])[CH:26]=1)[NH2:23].C(O)(=O)C>C(Cl)Cl>[F:19][C:20]1[CH:21]=[C:22]([N:23]=[C:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[N:8]([C:5]3[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=3)[C:9]2=[O:18])[CH:24]=[C:25]([F:27])[CH:26]=1参加物
5
実験手順
A mixture of 1-(4-hydroxyphenyl)-1H-indole-2,3-dione (30 mg, 0.126 mmol), 3,5-difluoroaniline (170 mg, 1.32 mmol), and a drop of acetic acid was heated at 140° C. for 4 hours in a 3 mL vial. The crude product was suspended in CH2Cl2 and purified by preparative TLC [Eluent: EtOAc/hexane (1:1)] giving the desired product. Procedure D