Carbon tetrabromide → 4-(Bromomethyl)-1-fluoro-2-methylbenzene

HRID 1375003ノート

反応式

HRID 1375003 の反応式
[C:1]([Br:5])(Br)(Br)Br.[F:6][C:7]1[CH:14]=[CH:13][C:10](CO)=[CH:9][C:8]=1[CH3:15].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[F:6][C:7]1[CH:14]=[CH:13][C:10]([CH2:1][Br:5])=[CH:9][C:8]=1[CH3:15]

参加物

5

反応物 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 2774592(4-Fluoro-3-methylphenyl)methanol

生成物 1

HCID 27781354-(Bromomethyl)-1-fluoro-2-methylbenzene収率 68%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Carbon tetrabromide (3.08 g) was added portion wisely to a solution of 4-fluoro-3-methylbenzylalcohol (1.3 g) and triphenylphosphine (2.9 g) in methylene chloride (50 ml) and the mixture was stirred for 1 hour. The solution was washed successively with saturated aqueous sodium hydrogen carbonate solution and brine, dried over sodium sulfate, and evaporated in vacuo. The residue was triturated with hexane and the resulting precipitate was removed by filtration. The filtrate was evaporated in vacuo and the residue was purified by column chromatography on silica gel with hexane as eluent to give 4-fluoro-3-methylbenzylbromide (1.28 g) as an oil.

後処理

  1. washThe solution was washed successively with saturated aqueous sodium hydrogen carbonate solution and brine
  2. dry with materialdried over sodium sulfate
  3. customevaporated in vacuo
  4. customThe residue was triturated with hexane
  5. customthe resulting precipitate was removed by filtration
  6. customThe filtrate was evaporated in vacuo
  7. customthe residue was purified by column chromatography on silica gel with hexane as eluent

出典と根拠

ORDレコード
ord-bc2e4e89bc8041c28726ada4c160f824
出典データセット
uspto-grants-2007_01
特許番号
US07166598B2

反応ノート

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