Hydrochloric Acid → 4-Methyl-3-(phenylsulfonyl)-cyclohexan-1-one

HRID 1375121ノート

反応式

HRID 1375121 の反応式
[Na+].[C:2]1([S:8]([O-:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][CH:12]1[CH2:17][CH2:16][C:15](=[O:18])[CH:14]=[CH:13]1.Cl>O>[CH3:11][CH:12]1[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH:13]1[S:8]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:10])=[O:9]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 2723840Benzenesulfinic acid, sodium saltHCID 109204694-Methyl-2-cyclohexenone

生成物 1

HCID 223949304-Methyl-3-(phenylsulfonyl)-cyclohexan-1-one収率 72%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Benzenesulfinic acid sodium salt (3.0 g) was added to a solution containing 1.52 g of 4-methyl-2-cyclohexene-1-one and 9 ml of water. 1N Hydrochloric acid (18 ml) was added dropwise to the resulting solution. After stirring at room temperature for 24 hours, the crystals so precipitated were filtered and washed with water, isopropanol and cold ethyl ether. After recrystallization from isopropanol, 4-methyl-3-(phenylsulfonyl)-cyclohexan-1-one (m.p.: 71–74) was obtained in the form of white crystals. Yield: 72%

後処理

  1. customthe crystals so precipitated
  2. filtrationwere filtered
  3. washwashed with water, isopropanol and cold ethyl ether
  4. customAfter recrystallization from isopropanol

出典と根拠

ORDレコード
ord-ec3de838a3d64b668355fea4efc13a9a
出典データセット
uspto-grants-2007_01
特許番号
US07166642B1

反応ノート

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