Isobutylamine → 4-Isobutyl-3-nitro quinoline
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH2:15](N)[CH:16]([CH3:18])[CH3:17].N(CCO)(CCO)CCO>C1(C)C=CC=CC=1>[CH2:15]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])[CH:16]([CH3:18])[CH3:17]参加物
5
実験手順
4-chloro-3-nitro-quinoline is reacted with isobutyl amine in the presence of triethanolamine (TEA) at between −10 and +15° C. in toluene, while excluding moisture. After washing and phase separation, the organic solution is ready for the next step.
後処理
- washAfter washing
- customphase separation
出典と根拠
- ORDレコード
- ord-141466dddea84eadb5617a749c199086
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07166721B2
反応ノート
読み込み中…